Enhancement of human IL-4 activity by soluble IL-4 receptorsin vitro

Enhancement of Il - 4 by Pertussis Toxin

The activity of soluble VCAM-1 in angiogenesis stimulated by IL-4 and IL-13.

IL-13 is a multifunctional lymphokine sharing a number of biological properties with IL-4. We previously observed that IL-4 shows angiogenic activities in vitro as well as in vivo. In this study we examined the effect of IL-13 on angiogenesis in vitro and in vivo and also the underlying mechanisms. Human IL-13 significantly stimulated the formation of tube-like structures in collagen gels by hu...

Detection of IL-4, IL-6 and IL-12 Serum Levels in Generalized Aggressive Periodontitis

Background: Periodontitis is a multifactorial chronic inflammatory disease characterized by destruction of tooth-supporting tissues. Environmental and genetic factors as well as the immune system participate in this process. Recent studies have attempted to elucidate the role of cytokine networks involved in periodontal diseases. Objective: To assess and compare the levels of IL-4, IL-6 and IL-...

Interleukin-4 (IL-4) Inhibits Secretion of IL-lfl, Tumor Necrosis Factor a, and IL-6 by Human Monocytes

Monocytes activated by lipopolysaccharide (LPS) and interferon y (IFNy) rapidly secrete a number of monokines with different functional properties. Interleukin-4 (IL-41, a T-cell derived cytokine, has been shown to reduce the production of monokines with cytostatic activity for tumor cells, chemotactic activity for monocytes, and factors that stimulate thymocyte proliferation. This latter activ...

Induction of functional IL-8 receptors by IL-4 and IL-13 in human monocytes.

IL-8 and related Glu-Leu-Arg (ELR+) CXC chemokines are potent chemoattractants for neutrophils but not for monocytes. IL-13 and IL-4 strongly increased CXCR1 and CXCR2 chemokine receptor expression in human monocytes, macrophages, and dendritic cells. The effect was receptor- and cell type-selective, in that CCRs were not increased and no augmentation was seen in neutrophils. The effect was rap...